Understanding the Active Ingredients present in Kratom

Published On October 20, 2017 | By James Colston | Health

MitragynaSpeciosa also known as Kratom is basically an herb having properties which are similar and matches with opioids. If you try to find location where this herb grows the most then you will find that it occurs in many regions of Indonesia, Thailand, Malaysia, and Papua New Guinea and also in major parts of Myanmar.

Use of the Kratom leaves are for making powder, tablets, tinctures, capsules, extracts, and many other things. This herb is used for alleviating musculoskeletal pain, to enhance energy level, for arousing sexual desire, and also appetite. In many areas of the world you will find its application for treating issues like hypertension, cough, and diarrhea Mitragynineis actually one of the main alkaloids which are found in Kratom. It creates 0.1 to 0.3% of thealkaloids. Many are not aware that even a small dose of this alkaloid behaves like stimulant for delta opioid receptors.

Kratom is having 40 alkaloids which act as active ingredients. These alkaloids play significant role on both opioid and monoaminergic receptors. The 2 major alkaloids are:

  • Mitragynine
  • Hydroxymitragynine

Aside to the above 2 some of the significant alkaloids includes:

  1. 1. Ajmalicine
  2. Mitraphylline
  3. Rhynchophylline
  4. Mitragyninepseudoindoxyl
  5. Raubasine
  6. Pausinystaliajohimbe
  7. Corynantheid
  8. Acetoxymitragynine
  9. Corynoxein
  10. Corinoxi

Apart from alkaloids Kratom contains terpenoid saponins, glycosides, flavonoids and many other polyphenols.

  1. Mitragynine: Do you know that, 5-HT2a as well as postsynaptic α2-adrenergic receptors, along with neuronal Ca2+ channels are responsible for unique pharmacological and behavior of mitragynine.If one takes it of higher doses, then it will act well as painkiller byresponding with mu opioid receptors. There is no chance for any type ofpsychedelic effects. Yes, it’s true that itcomes with some drug interactions and same gets inhibited with CYP3A4, CYP2D6, and CYP1A2 enzymes.

B. Hydroxymitragynine: Another important active ingredient which is present in Kratom is Hydroxymitragynine and it is an opioid agonist. If we check we will find that it is more potent when compared withmitragynine. Hydroxymitragynineinteracts really well with Kappa, Delta, and also with Mu opioid receptors, but in maximum cases it behaves like an agonist at the Mu receptors. It leads to analgesia along with physical dependence.

Many come with the question as how safe it is to use Kratom. Well the answer is yes its safeand you can use without thinking much as it’s just not safe its absolute 100% safe to use. All that you need to remember and be careful is about the dose. If same is taken in required amount then it will be completely safe for you to use.

If in case users takes overdose of Kratom, then he or she may feel over excited followed by a feeling of slight giddiness, tiredness, lacking in motor coordination and also hyperpigmentation on the cheeks. In short we can say that Kratom is quite safe choice to consume. Its benefits are so much that its mild side effects can be easily overlooked and managed.

 

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